新取代苯基荧光酮试剂的合成及其性质的研究Ⅰ．新型取代苯基荧光酮的合成、提纯、鉴定及离解的研究

合成了３，５－二溴－４－氨基苯基荧光酮、４－偶氮变色酸苯基荧光酮、３，５－二溴－４－氨基变色酸苯基荧光酮、４偶氮肿Ⅰ苯基荧光酮、３，５－二溴－４－偶氮胂Ⅰ苯基荧光酮、４－偶氮间苯二酚苯基荧光酮、３，５－二溴－４－偶氮间并苯二酚苯基荧光酮和３，５－二溴－４－二甲氨基过溴化物苯基荧光酮等８种新有机试剂。对其进行了提纯和结构鉴定，并对试剂离解状态及离解常数进行了研究和测定。     

Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity

It has been observed that herpes simplex virus mutants with deficient or altered thymidine kinase activity are more susceptible to Cidofovir (CDV; 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine dihydrate) in tissue culture than are the parental strains. During infection of cells, the elevation of the dCTP pool by thymidine kinase mutant viruses is less than that induced by the wild-type virus. The competition between CDV diphosphate and dCTP at the viral polymerase is therefore changed in favor of CDV diphosphate, enhancing its activity.     

The use of force modulation microscopy to investigate block copolymer morphology

Force modulation microscopy (FMM) is used to characterize the external surface and internal fracture surface morphologies of three different block copolymer samples. A roll-cast poly(styrene-butadiene-styrene) triblock copolymer film, spin-coated poly(styrene-b-methyl methacrylate) thin films, and an ultrathin poly(styrene-b-hexyl isocyanate) rod-coil block copolymer film were investigated. For each sample, height and elasticity images were obtained for the same areas allowing direct comparison. The elasticity images obtained using force modulation microscopy were independent of surface roughness and found to exhibit better contrast and spatial resolution of the respective block copolymer domains than the height images. The lateral resolution of the elasticity images was sufficient to show microphase separated domains having length scales as small as about 10 nm. The poly(styrene-b-methyl methacrylate) samples demonstrate that FMM can even be successfully used to study block copolymers in which both blocks are glassy under the conditions of measurement.     

Dielectric characteristics of composite ceramics in the Ba(Mg1/3Ta2/3)O3-BaO · Nd2O3 · 5TiO2 system

Dielectric characteristics of composite ceramics in the system Ba(Mg_1/3Ta_2/3)O₃-BaO · Nd₂O₃ · 5TiO₂ were investigated to search for a new candidate system for microwave dielectric ceramics with modifiable dielectric constant, low dielectric loss and small temperature dependence. The dielectric constant could be adjusted in the range 25–81 by controlling the concentration of BaO · Nd₂O₃ · 5TiO₂, while the dielectric loss remained of the order of 10^–4 for some compositions. Moreover, the dielectric properties in the present system could be significantly improved by post-densification thermal treatment.     

金属蒸气法制备聚合物固载Pd－Cu双金属原子簇

为了不使用任何还原剂而获得聚合物固载高分散零价双金属加氢催化剂，利用金属蒸气法制备了３种不同Ｐｄ／Ｃｕ质量比的聚合物固载双金属原子簇。透射电镜（ＴＥＭ）和Ｘ衍射（ＸＲＤ）测定表明，Ｐｄ－Ｃｕ原子簇粒度很小，平均直径小于３．０ｎｍ。Ｘ射线光电子能谱（ＸＰＳ）表明，Ｐｄ和Ｃｕ均为零价态。Ｐｄ－Ｃｕ原子簇在异丙叉加氢反应中具有很高的活性和选择性。这些结果提供了令人信服的证据，即金属蒸气法可用于在聚合物孔穴内直接而温和地置入小的零价金属原子簇，而且这样制备的聚合物固载金属原子簇很适合于催化应用。     

旋转机械故障诊断的自学习方法研究

分析并介绍了旋转机械故障诊断的模糊数学与专家系统相结合的诊断方法，提出了一种实用的自学习策略，用这一诊断方法在实验室对一双跨转子进行了两种常见故障的学习及诊断。并将该学习模块装入现场一台５０ＭＷ汽轮发电机组的故障诊断专家系统中，经过多年运行，专家系统知识库得到不断完善。     

激光诱变遗传的共振激发及非线性作用机理分析

用量子力学及非线性科学理论，研究了激光与脱氧核糖核酸（ＤＮＡ）分子相互作用的共振吸收效应及混沌性质，进而对激光的生物诱变效应予以解释。     

东阳八达水电站拱坝蓄水设计

为解决八达水电站拱坝施工过程中出现的具体问题，提出了几种可能的方案，并对选定方案进行了大量的计算，最后确定采用二次封拱和下游坝面喷淋冷却水方案。既符合规范要求，也满足坝体应力的控制要求。实施后效果良好。     

结构性黄土湿陷性指标室内测定方法的探讨

对黄土湿陷性指标的室内测定，国内外都借助标准压密仪，采用单线法或双线法进行。由于多种原因，我国各部委编制的试验规程，对采用何种方法，意见尚未统一。本文首先从人工制备结构性黄土的试验成果出发，讨论了黄土的湿陷线问题，认为非饱和结构性黄土存在湿陷线，且该线与饱和结构性黄土的压密曲线重合。从而说明在此简单应力路径下，单线法和双线法是等价的。接着，从日本大阪海成粘土不同室内压密方法得出的试验结果出发，就天然结构黄土，探讨了常规标准压密试验方法的不足，提议采用等应变压密双线法，来测定结构性黄土的湿陷性指标，从而有利于实际工程应用。